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Buy MPHP powder 4′-Methyl-α-pyrrolidinohexiophenone

(2 customer reviews)

$20.00 $15.00 PRICE PER GRAM

Quantity Price
1 - 29 $15.00
30 - 49 $12.00
50 - 99 $10.00
100 - 499 $7.00
500+ $5.00
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Description

Buy MPHP powder 4′-Methyl-α-pyrrolidinohexiophenone

Buy MPHP powder 4′-Methyl-α-pyrrolidinohexiophenone is a stimulant compound which has been reported as a novel designer drug. It is closely related to pyrovalerone, being simply its chain-lengthened homologue. In the pyrrolidinophenone series, stimulant activity is maintained so long as the positions of the aryl,

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ketone and pyrrolidinyl groups are held constant, while the alkyl backbone can be varied anywhere between three and as many as seven carbons, with highest potency usually seen with the pentyl or isohexyl backbone, and a variety of substituents are tolerated on the aromatic ring.

In 2010 a group of researchers from the Institute of Forensic Medicine, University Hospital Jena, Germany concluded that MPHP can lead to serious poisoning with toxic liver damage and rhabdomyolysis.

Reagents and materials

MPHP and 4′-methoxy-α-pyrrolidinopropiophenone (MeOPPP) were purchased from Cayman Chemical Co. (Ann Arbor, MI, USA). Other common chemicals were of analytical grade and purchased from Wako Pure Chemical Industries Ltd. (Osaka, Japan).

 

Blank blood and urine samples were collected from healthy volunteers with no history of drug intake after informed consent was obtained. The blank samples were screened for common drugs of abuse, alcohol, and MPHP and all were confirmed to be negative.

ampling and sample preparation

Heart blood, urine, and liver tissue samples were collected at autopsy. The blood samples were centrifuged at 1600×g for 10 min immediately after autopsy to prepare plasma. The plasma, urine and liver tissue samples were stored at −20 °C until use.

Buy MPHP powder 4′-Methyl-α-pyrrolidinohexiophenone

Liver tissue specimens were homogenized with 4 times (v/w) the amount of ultra-pure water using a bead beater-type shaking machine (TissueLyser II; QIAGEN, Hilden, Germany), and then the homogenate was diluted two-fold with ultra-pure water. Forty-five microliter samples of plasma, urine, or diluted liver tissue homogenate were deproteinized with 100 μL of acetone, and followed by the addition of 5 μl of 1.0 μg/mL MeOPPP as an internal standard. After centrifugation at 10,000×g for 5 min, the supernatant was used for LC–TOF-MS analyses.

LC–TOF-MS conditions

LC–TOF-MS conditions were exactly the same as described in our previous report []. Briefly, LC–TOF-MS was conducted on a Waters ACQUITY UPLC system with a quadrupole time-of-flight MS system (Xevo® G2-S QTof; Waters). LC separation was performed with a Waters ACQUITY UPLC HSS C18 column (2.1 × 150 mm, 1.8 mm i.d., 1.8 μm particle size) with an aqueous solution of 5 mM ammonium formate adjusted to pH 3.0 using formic acid (solvent A) and an acetonitrile solution containing 0.1 % (v/v) formic acid (solvent B) for the mobile phases. The gradient elution mode was employed using the solvents A and B as described

Who should be referred? 

The MPHP helps professionals who suffer from substance use illnesses, mental illness, behavioral disorders, or who are experiencing legal issues related to any of the above.  The Program and Advisory Committee are advocates for colleagues whose health problems may compromise their professional and personal lives.  The MPHP is able to serve healthcare professionals licensed by the following Maine boards: Dental, Medical, Nursing, Osteopathic, Pharmacy, and Veterinary- or residents and students in any of these fields.

 

UPAC Name: 1-(4-methylphenyl)-2-(pyrrolidin-1-yl)hexan-1-one
CAS#: 34138-58-4
Synonyms: 4′-Methyl-a-pyrrolidinohexiophenone, 4′-Me-a-
4′-Methyl-a-pyrrolidinohexanophenone, PV-4, 4′-MePHP

Synthetic Cathinones

Recently, novel synthetic cathinones that mimic the biological effects of substances with stimulant-like effects have emerged on the illicit drug market. These novel cathinones, also known as designer drugs, are structurally similar to several drugs of abuse such as schedule I synthetic cathinones (e.g., methcathinone, mephedrone, methylone, pentylone, and 3,4-methylenedioxypyrovalerone (MDPV)).

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With many generations of synthetic cathinones having been encountered since 2009, the abuse of N-ethylhexedrone, α-PHP, 4-MEAP, MPHP, PV8, and 4-chloro-α-PVP is impacting or will negatively impact communities.

2 reviews for Buy MPHP powder 4′-Methyl-α-pyrrolidinohexiophenone

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